Mudanya University Institutional Academic Archive System
Mudanya University's Dspace system is a platform that digitally stores and opens academic studies. Academic content such as articles, presentations, theses, books, and reports are included here. Dspace@Mudanya provides easy access, making it a valuable resource for researchers and students. It serves as a digital archive for Mudanya University's academic outputs, facilitates access to scientific information and supports its sharing. For more information and assistance, please contact us.
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The Role of Advanced Glycation End Products in Saphenous Vein Graft Failure
(Karger, 2024-10) Akgümüş, Alkame; Boyraz, Bedrettin; Balun, Ahmet; 313898
Objective: We aimed to investigate the relationship between advanced glycation end product (AGE) levels in patients with saphenous vein graft (SVG) failure and in patients without SVG failure.
Subjects and Methods: In our study, 55 patients with a history of previous coronary artery bypass grafting (CABG) surgery, who subsequently underwent coronary angiography for any reason and were found to have either SVG occlusion or significant lesions, were included as study patients. Additionally, 55 patients who have had CABG surgery without SVG failure for at least 1 year served as the control group. AGE values of the patients were measured using the skin autofluorescence method.
Results: In our study results, we observed a significant difference in AGE levels between the two groups of patients with similar demographic characteristics (SVG failure groups AGE 3.2 [2.8–3.6] vs. control groups AGE 2.4 [2.1–2.7] p < 0.001). In the receiver operating characteristic curve analysis, we determined the ability of AGE levels to detect SVG failure with an area under the curve of 0.869. We found that in patients with AGE >3, it could detect SVG failure with a sensitivity of 70.9% and a specificity of 87.3%. Conclusions: Our results demonstrate that AGE levels can predict SVG failure risk inexpensively, easily, and quickly.
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Outcomes of Liver Transplantation in Infants: A Retrospective Cohort Study
(Elsevier, 2024-12) Erbiş, Halil; Kılınç, Eyyüp Mehmet; Fırat, Aynur; Aliosmanoğlu, Çiğdem; Ağca, Mevlüt Harun; Aliosmanoğlu, İbrahim; 104930
Background. Liver transplantation (LT) is a crucial treatment for infants with end-stage liver disease, yet specific data on LT outcomes in infants under 12 months old remain limited. This study aims to present the clinical course and outcomes of infants who underwent LT, assessing the impact of demographic and etiological differences on mortality and survival. Methods. A retrospective analysis was conducted on 64 infants (< 12 months) who underwent LT between January 2019 and March 2024. Demographic, clinical, and laboratory data were collected from their medical records. LT-specific details, postoperative complications, and survival data were analyzed. Results. The median age of the infants was 157 days, with 37 boys (57.8%) and 27 girls (42.2%). Biliary atresia was the most common diagnosis (85.9%), and seven infants had undergone a previous Kasai procedure. The median pediatric end-stage liver disease (PELD) score was 15.5. Left lateral segmentectomy was the predominant graft type (60.9%). The median pediatric intensive care unit (PICU) and hospital stays were 5 and 21 days, respectively. Complications occurred in 20 infants (31.3%), with vascular and biliary complication rates both at 12.5%. The overall mortality rate was 17.2%, with early (30-day) and late mortality rates of 6.3% and 10.9%, respectively. The median overall survival (OS) was 204.5 days, and the 1-year survival rate was 32.8%. Kaplan-Meier and log rank analyses showed no significant impact of sex, age, diagnostic groups, graft type, or surgical complications on OS (P> .05). Conclusions. LT in infants can be performed with acceptable morbidity and mortality rates, particularly with increased experience and standardized protocols.
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Exploring Cognitive Enhancements and Default Mode Network Connectivity in Relapsing-Remitting Multiple Sclerosis: Insights from a Prospective Study Investigating the MIND Diet
(Sage, 2024-09) Demirel, Mert; Daşgın, Hacer; Acar, Nazire Pınar; Özçelik-Eroğlu, Elçin; Atabilen, Büşra; Ertuğrul, Aygün; Akdevelioğlu, Yasemin; Oğuz, Kader Karlı; Tuncer, Meryem Aslı; 396621
The potential therapeutic impact of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet on relapsing-remitting multiple sclerosis (RRMS) remains an underexplored area.
Objectives/Aims: This study aims to evaluate the influence of the MIND diet on RRMS by examining neurological, cognitive, and functional magnetic resonance imaging (fMRI) parameters.
Methods: Seventeen early-stage RRMS patients (aged 20-40, disease duration < 10 years, Beck Depression Inventory Score < 17) underwent MRI at baseline and following a 9-month adherence to the MIND diet. They were matched with 10 healthy controls. Diet adherence was assessed using the MIND Diet scale score. MRI encompassed structural and resting-state fMRI (RS-fMRI) sequences. Neurological evaluation (Expanded Disability Status Scale [EDSS], Timed 25-Foot Walk [T25W], 9-Hole Peg Test [9HPT]), and cognitive assessments (Mini-Mental State Examination [MMSE], Rey Auditory Verbal Learning Test [AVLT], phonemic and semantic fluency, forward and backward digit span tests [FDST, BDST]) were conducted. Functional connectivity was assessed using seed-based correlation (SBC) and global correlation by general linear model (GLM), focusing on Default Mode Network (DMN), Central Executive Network (CEN), Dorsal Attention Network (DAN), Salience Network (SN), Visual Network (VN), and Sensorimotor Network (SMN).
Results: Patients exhibited high adherence to the diet throughout the 9-month period. Significant improvements were observed in dominant hand 9-HPT (p=0.023) and AVLT parameters (p<0.001), except delayed recall (p=0.982), following the intervention. Increased connectivity within the whole brain was noted in the left frontal orbital cortex of the 9th-month group compared to healthy controls (p=0.000005). Moreover, RRMS patients in the 9th-month group displayed enhanced functional connectivity in the bilateral caudate, bilateral pallidum, and right putamen within the DMN compared to baseline (p=0.000034).
Conclusion: The findings of this study suggest potential cognitive benefits of the MIND diet, as evidenced by improvements in AVLT scores. Furthermore, the observed alterations in Default Mode Network (DMN) connectivity in RRMS patients following the dietary intervention indicate a promising avenue for further investigation into cognitive deficit management in this population
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Testing the Forecasting Power of Statistical Models for Intercity Rail Passenger Flows in Turkey
(Sage, 2024-11) Ekici, Üsame; Tüydeş Yaman, Hediye; Şendil, Nuri
While going through a major rail transformation, it is important to develop reliable estimation models for rail passenger flows (RPFs) in Turkey. There are two main approaches in RPF estimation, regressions and autoregressive integrated moving-average (ARIMA) models, both of which were in this study developed using the daily RPF data for the period 2011–2015. The ARIMA models (with some variations) were used to forecast first the daily flows in 2016, during which travel restrictions for summer resulted in reduced volumes, successfully captured in the updated ARIMA model. The regression models predicted the expected demand during the restrictions, enabling evaluation of the impact of restrictions, which also showed the models’ power over the longer term. The forecasts were extended to 2017, 2018, and 2019 data. The regression results produced more reliable forecasts over the long term, whereas more accurate predictions were obtained by ARIMA-Sliding (FA-Sld) for short-term planning purposes.
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Dams in the wake-up call of the 2023 Türkiye earthquake sequence: Insights from observed damages, risk assessment, and monitoring
(Elsevier, 2024-01) Hariri-Ardebili, Mohammad Amin; Tosun, Hasan
On February 6, 2023, Türkiye experienced a significant earthquake with a magnitude of 𝑀𝑤 7.81, followed by four additional earthquakes throughout the day, measuring 𝑀𝑤 5.8 and above, including one with a 𝑀𝑤 7.5. As a result, over 100 dams in the region experienced low to high seismic loads. The impact of these seismic events resulted in a range of damages to dams, varying from light to severe. The authors participated in several post-earthquake reconnaissance missions to collect perishable data regarding the damage. This paper is threefold: First, it explores the seismic performance and observed damage in 17 dams (majority embankments) based on data collected from the field. During the seismic activity, embankment dams underwent failure modes such as strength deterioration, yielding, settlement, tension crack formation, as well as sliding along planar or circular surfaces. Second, the paper offers an updated seismic risk analysis for ten selective damaged dams in the regions. Total risk factors are quantified using two different methods. The results show that the majority of the studied dams are classified as high and very high-risk dams. Third, the paper evaluates 11 other dams in the region that were equipped with sensors for monitoring the ground motions. The recorded acceleration at the crest and the abutment are further used to investigate the amount of amplification based on transfer functions. These recordings will be crucial for subsequent model calibration and system identification. Overall, the paper’s objective is to contribute to sharing post-earthquake reconnaissance mission information and to establish the groundwork for in-depth numerical analyses and quantitative risk assessments of dams located in seismically vulnerable areas.
