Bilgisayar Mühendisliği Bölümü Koleksiyonu
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- ItemAn explainable ensemble machine learning model using baseline blood transcriptomics to predict Parkinson’s disease motor progression(FRONTIERS MEDIA SA, 2026-02) Fırat, Yelda; 41749Introduction: Predicting Parkinson's disease (PD) motor progression remains challenging despite advances in neuroimaging. Blood-based transcriptomic profiling offers a more accessible and cost-effective alternative. This study aimed to develop and validate a machine learning approach using blood-based transcriptomic data to predict 12-month motor severity in PD and to identify the transcriptomic features and biological pathways most strongly associated with progression. Methods: A Stacking Regressor ensemble model combining three gradient boosting algorithms (XGBoost, LightGBM, CatBoost) was developed using baseline Parkinson's Progression Markers Initiative (PPMI) data (n = 390), integrating blood RNA sequencing (RNA-seq) and clinical features to predict 12-month UPDRS Part III scores. SHapley Additive exPlanations (SHAP) analysis was applied to identify key prognostic features, evaluating seven PD risk genes (SNCA, LRRK2, GBA, PRKN, PINK1, PARK7, VPS35) and pathway scores for mitochondrial dysfunction, neuroinflammation, and autophagy. Results: On an independent test set (n = 78), the model achieved a Coefficient of Determination (R & sup2;) of 0.551 and Mean Absolute Error (MAE) of 6.01. SHAP analysis identified the baseline UPDRS & times; PINK1 interaction (UPDRS_BL & times; PINK1) as the most influential feature (mean |SHAP| = 0.283). Among transcriptomic features, VPS35 (mean |SHAP| = 0.010), GBA, and LRRK2 were most prominent. Mitochondrial dysfunction showed the highest pathway contribution (mean |SHAP| = 0.008). Discussion: The study establishes that machine learning integrating blood transcriptomics and clinical data effectively predicts motor progression in PD. Crucially, the interplay between initial clinical state and specific genetic backgrounds-particularly PINK1-is a more powerful prognostic indicator than any factor alone. This study provides systematic evidence that mitochondrial dysfunction is a dominant prognostic signal for disease progression, nominating key genes and pathways for future mechanistic and therapeutic investigation.
- ItemSHAP-based explainable AI framework for autism severity classification using 3D motor biomarkers(FRONTIERS MEDIA SA, 2026-03) Fırat, Yelda; 41749Introduction Early Autism spectrum disorder (ASD) diagnosis is critical for intervention, yet current methods rely on subjective clinical observations. This study develops objective tools to classify ASD severity using 3D motor movement analysis, addressing motor abnormalities as core diagnostic features.Methods A Random Forest (RF) model classified three severity levels using 463 motor features from 25 Kinect V2 joint points. Data from 109 children (50 typical, 50 moderate ASD, 9 severe ASD) were validated via 5-fold cross-validation and two held-out test sets (20% each). Shapley Additive Explanations (SHAP) analysis identified critical motor biomarkers.Results The model achieved 84.6 +/- 10.9% accuracy (5-fold cross-validation) and 86.4% accuracy (internal and held-out test sets). For severe ASD, the model achieved 100% classification accuracy on synthetic test data (4/4 cases; 95% CI: 39.8%-100.0%). However, this result represents a methodological proof-of-concept rather than clinical validation, as severe ASD features were synthetically generated from moderate ASD data and the model has not been validated on real Kinect-derived severe ASD motor data. SHAP analysis identified wrist movements, knee trajectories, and elbow-to-foot distances as key motor biomarkers for severity classification.Discussion This Kinect-based approach with RF and SHAP offers effective, interpretable ASD severity assessment for typical and moderate ASD classes, with promising methodological foundations for severe ASD pending validation on real data.
- ItemDeep Learning-Based Detection of Motor Biomarkers for Autism from Children's Natural Home Video Recordings(GRAZ UNIV TECHNOLGOY, INST INFORMATION SYSTEMS COMPUTER MEDIA-IICM, 2026-05) Fırat, Yelda; Kılıçaslan, Yılmaz; Sarıkaya, Hasan Ali; Yılmaz, Murat Kaan; 41749Autism Spectrum Disorder is a neurodevelopmental disorder with onset in early childhood and its diagnosis often requires clinical processes based on long, subjective observations. Although early diagnosis and intervention can significantly improve developmental outcomes, existing methods are limited in terms of scalability and objectivity. The aim of this study is to develop a hybrid deep learning model that detects Autism Spectrum Disorder with high accuracy by analyzing motor behaviors from videos of children recorded in their natural home environment. In this study, joint coordinates were extracted using the MediaPipe Pose model and spatial, temporal, frequency and coordination-based features were calculated from these data. The features were processed with a hybrid architecture integrating CNN, BiLSTM and attention mechanism. CNN captured spatial patterns, BiLSTM learned the dynamics over time, and the attention mechanism focused on critical movement segments. The model achieves over 97% accuracy on closed datasets and over 83% on public videos such as YouTube and TikTok. These results show that the method performs robustly under both controlled and real-world conditions. The study provides a scalable, objective and clinically applicable screening tool that overcomes the problems of artificial environments and limited data.
- Itemİş süreci optimizasyonu: yöntem, teknoloji, riskler ve fırsatlar(Bitlis Eren Üniversitesi, 2023) Şahinaslan, Ender; 122635Süreç optimizasyonu, iş süreci yönetiminin ayrılmaz bir parçasıdır. İşletmelerin mevcut iş süreçlerini ve çalışma biçimlerini anlamaları ve iyileştirmeleri için bir fırsattır. İyi bir strateji ile yürütülen süreç optimizasyon çalışmaları, işletmelere maliyet tasarrufu, zaman tasarrufu, artan verimlilik, azalan hatalar ve müşteri memnuniyeti gibi birçok avantaj sağlamaktadır. Bunlar bir yandan işletmenin performansını artırırken diğer yandan sürdürülebilir bir büyümeye de katkı sağlar. Öte yandan günümüz rekabet koşulları, teknolojik yenilikler ve dijital dönüşüm çabaları kurumsal işletmeleri iş süreçlerini iyileştirmeye ve optimize etmeye zorlamaktadır. Böyle bir çalışmada yöntem, teknik ve uygulama pratiklerinin bir arada sunulduğu rehber çalışmalara ihtiyaç vardır. Bu çalışma, süreç iyileştirme ve optimizasyona özel literatür kaynakları, eğitim notları ve saha uygulamalarından elde edilen deneyimlerin sentezlenmesi şeklindedir. Çalışmada süreç optimizasyonunun temel kavramı ve tanımı, süreç optimizasyonunun ne olduğu ve neden önemli olduğu, süreç iyileştirme ve optimizasyon yöntemleri, adımları ve ilgili teknolojiler açıklanmakta, süreç optimizasyonu adımları, güncel yaklaşımlar, teknoloji kullanımı, riskler ve fırsatlar ele alınmaktadır. Bu çalışma, iş süreçlerinin iyileştirilmesine ve optimize edilmesine yardımcı olabilecek bir rehber olarak literatüre katkı sağlamak amacıyla hazırlanmıştır.
- ItemA modern approach to data privacy with federated learning(Maltepe University, 2023) Kalkavan, Ziya Can; Şahinaslan, Ender; Şahinaslan, Önder; 122635Today, information technologies and their usage areas are increasing day by day. Advanced technologies such as the internet of things, smart devices and applications, machine learning and arti cial intelligence are a driving force in the spread of their usage areas. The increase in prevalence and use also increases the production and sharing of data. This increase causes various security problems and concerns in terms of data privacy. Therefore, a balance has to be struck between the need for data sharing and its security. For this purpose, the use of federated learning methods has been examined. Traditional data sharing methods focus on centralized solutions for the processing of private and sensitive data of data subjects, but this causes various problems and raises concerns in the sharing of sensitive data. In the federated learning model, it trains locally without data sharing. It has a distributed arti cial intelligence approach that can run di erent resources together. Thus, it o ers an alternative solution that can help address data privacy concerns arising from the traditional method. In this study, the basic principles, usage areas, advantages and difficulties of federated learning, which is also accepted as a modern approach in data privacy, are discussed. The data and examples obtained in the study will be presented.
