Investigation of pepsin levels in bronchial lavage in patients with interstitial lung disease and chronic cough

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dc.authorid0000-0001-8165-234X
dc.contributor.authorAla Çitlak, Fatma Selen
dc.contributor.authorKöksal, Nurhan
dc.contributor.authorAvci, Bahattin
dc.contributor.authorTibel Tuna, Nazmiye
dc.contributor.authorGüllü, Yusuf Taha
dc.contributor.authorid156045
dc.date.accessioned2025-03-18T13:22:39Z
dc.date.available2025-03-18T13:22:39Z
dc.date.issued2024-11
dc.departmentFakülteler, Meslek Yüksekokulu, Anestezi Bölümü
dc.descriptionScience Citation Index Expanded (SCI-EXPANDED)
dc.description.abstractAim: Pepsin is an enzyme that helps digest protein secreted only from the gastric chief cell in an inactive state. Pepsin is a good marker for acidic gastroesophageal reflux (GER). Its presence in sputum or saliva is considered pathologic. In GER, cough is stimulated by broncho-esophageal neurogenic reflex and aspiration of gastric contents into the airways. GER is the most common cause of cough. Gastric acid reflux is also thought to play a role in Interstitial Lung Disease (ILD) etiology. In many studies, pepsin and bile acid levels in bronchial lavage were high in patients with interstitial lung disease and chronic cough. In our study, we aimed to evaluate pepsin levels in bronchial lavage in patients with ILD and chronic cough and to investigate the relationship between symptoms and reflux treatment. Methods: Between January 2021 and February 2022, 212 patients who underwent bronchoscopy in our tertiary clinic were evaluated. These patients were divided into three groups: 52 patients with interstitial lung disease, 81 patients with chronic cough, and 79 patients who underwent bronchoscopy with a pre-diagnosis of lung cancer as the control group. Bronchial lavage obtained by bronchoscopy was analyzed for pepsin levels. Results: Shortness of breath and cough were the most common symptoms in all three groups. Pepsin levels were 16.71 ± 8.6 ng/ml in the chronic cough group, 15.6 ± 8.9 ng/ml in the ILD group, and 10.58 ± 5.4 ng/ml in the lung cancer (control) group. Pepsin levels in the ILD and chronic cough group were statistically significantly higher than in the lung cancer group (p:0.00). There was no statistical difference between the ILD group and the chronic cough group regarding pepsin levels. It was found that pepsin levels were lower in the three groups who received anti-reflux treatment. There was no difference in pepsin levels between ILD subgroups. Conclusion: Pepsin levels in bronchial lavage were higher in the ILD and chronic cough groups. This suggests that reflux may be involved in the etiology of chronic cough and ILD. Low pepsin values in patients receiving antireflux therapy have shown that occult reflux may occur. In our study, the high level of pepsin in bronchial lavage, especially in the chronic cough and ILD group, may be instructive in the etiology and treatment planning of the disease.
dc.identifier.citationAla Çitlak, F. S., Köksal, N., Avci, B., Tibel Tuna, N. & Güllü, Y. T. (2024). Investigation of pepsin levels in bronchial lavage in patients with interstitial lung disease and chronic cough. Respiratory Medicine, 233, 1-5. https://doi.org/10.1016/j.rmed.2024.107781
dc.identifier.doi10.1016/j.rmed.2024.107781
dc.identifier.eissn1532-3064
dc.identifier.endpage5
dc.identifier.issn0954-6111
dc.identifier.pmid39182853
dc.identifier.scopus2-s2.0-85202189908
dc.identifier.startpage1
dc.identifier.urihttps://dspace.mudanya.edu.tr/handle/20.500.14362/300
dc.identifier.volume233
dc.identifier.wosWOS:001302776500001
dc.identifier.wosqualityQ1
dc.institutionauthorGüllü, Yusuf Taha
dc.language.isoen
dc.publisherElsevier
dc.relation.journalRespiratory Medicine
dc.relation.publicationcategoryMakale- Uluslararası- Hakemli Dergi- Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBronchial lavage
dc.subjectPepsin
dc.subjectChronic cough
dc.subjectInterstitial lung disease
dc.subjectLung cancer
dc.titleInvestigation of pepsin levels in bronchial lavage in patients with interstitial lung disease and chronic cough
dc.typeMakale
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