Outcomes of Liver Transplantation in Infants: A Retrospective Cohort Study

Simple item page
dc.authorid0000-0003-1470-7501
dc.contributor.authorErbiş, Halil
dc.contributor.authorKılınç, Eyyüp Mehmet
dc.contributor.authorFırat, Aynur
dc.contributor.authorAliosmanoğlu, Çiğdem
dc.contributor.authorAğca, Mevlüt Harun
dc.contributor.authorAliosmanoğlu, İbrahim
dc.contributor.authorid104930
dc.date.accessioned2025-03-13T10:46:03Z
dc.date.available2025-03-13T10:46:03Z
dc.date.issued2024-12
dc.departmentFakülteler, Meslek Yüksekokulu, Anestezi Bölümü
dc.descriptionScience Citation Index Expanded (SCI-EXPANDED)
dc.description.abstractBackground. Liver transplantation (LT) is a crucial treatment for infants with end-stage liver disease, yet specific data on LT outcomes in infants under 12 months old remain limited. This study aims to present the clinical course and outcomes of infants who underwent LT, assessing the impact of demographic and etiological differences on mortality and survival. Methods. A retrospective analysis was conducted on 64 infants (< 12 months) who underwent LT between January 2019 and March 2024. Demographic, clinical, and laboratory data were collected from their medical records. LT-specific details, postoperative complications, and survival data were analyzed. Results. The median age of the infants was 157 days, with 37 boys (57.8%) and 27 girls (42.2%). Biliary atresia was the most common diagnosis (85.9%), and seven infants had undergone a previous Kasai procedure. The median pediatric end-stage liver disease (PELD) score was 15.5. Left lateral segmentectomy was the predominant graft type (60.9%). The median pediatric intensive care unit (PICU) and hospital stays were 5 and 21 days, respectively. Complications occurred in 20 infants (31.3%), with vascular and biliary complication rates both at 12.5%. The overall mortality rate was 17.2%, with early (30-day) and late mortality rates of 6.3% and 10.9%, respectively. The median overall survival (OS) was 204.5 days, and the 1-year survival rate was 32.8%. Kaplan-Meier and log rank analyses showed no significant impact of sex, age, diagnostic groups, graft type, or surgical complications on OS (P> .05). Conclusions. LT in infants can be performed with acceptable morbidity and mortality rates, particularly with increased experience and standardized protocols.
dc.identifier.citationErbiş, H., Kılınç, M. E. Fırat, A. ... (2024). Outcomes of Liver Transplantation in Infants: A Retrospective Cohort Study. Transplantation Proceedings, 56(10), 2213-2218. https://doi.org/10.1016/j.transproceed.2024.10.028
dc.identifier.doi10.1016/j.transproceed.2024.10.028
dc.identifier.eissn1873-2623
dc.identifier.endpage2218
dc.identifier.issn0041-1345
dc.identifier.issue10
dc.identifier.startpage2213
dc.identifier.urihttps://dspace.mudanya.edu.tr/handle/20.500.14362/298
dc.identifier.volume56
dc.identifier.wosWOS:001388627700001
dc.identifier.wosqualityQ4
dc.institutionauthorFırat, Aynur
dc.language.isoen
dc.publisherElsevier
dc.relation.journalTransplantation Proceedings
dc.relation.publicationcategoryMakale- Uluslararası- Hakemli Dergi- Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleOutcomes of Liver Transplantation in Infants: A Retrospective Cohort Study
dc.typeMakale
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Outcomes of Liver Transplantation in Infants A Retrospective Cohort Study.pdf
Size:
489.77 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.8 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
Anestezi Bölümü Koleksiyonu