Multimodal imaging analysis of autosomal recessive Parkinson’s disease

Simple item page
dc.authorid0000-0003-4372-1134
dc.authorwosidLIG-7707-2024
dc.contributor.authorSoydaş Turan, Başak
dc.contributor.authorYalçın Çakmaklı, Gül
dc.contributor.authorLay Ergün, Eser
dc.contributor.authorDaşgın, Hacer
dc.contributor.authorKarlı Oğuz, Kader
dc.contributor.authorElibol, Bülent
dc.contributor.authorUğur, Ömer
dc.contributor.authorVolkan Salancı, Bilge
dc.contributor.authorid396621
dc.date.accessioned2025-04-30T07:01:35Z
dc.date.available2025-04-30T07:01:35Z
dc.date.issued2025-04
dc.departmentFakülteler, Meslek Yüksekokulu, Tıbbi Görüntüleme Teknikleri Bölümü
dc.descriptionScience Citation Index Expanded (SCI-EXPANDED)
dc.description.abstractObjective Pathophysiological backgrounds of idiopathic Parkinson’s disease (IPD) and autosomal recessive monogenic Parkinson’s disease (AR-PD) have common features that can be assessed through multimodal imaging. In this study, the striatal and myocardial dopaminergic innervation, brain 18F-FDG metabolism, resting-state functional activity of basal ganglia network (BGN) and white-matter (WM) microstructure were evaluated in AR-PD with respect to IPD, to investigate whether AR-PD can be subtyped as “brain-first” parkinsonism according to recent etiopathogenetic classification effort. Methods Forty patients (17 with Parkin, 3 with DJ-1 mutations and 20 with IPD) were included. Striatal dopaminergic innervation was assessed semi-quantitatively by 18F-DOPA PET, and cardiac 18F-DOPA uptake was also evaluated. Brain 18F-FDG PET images were evaluated visually. Resting-state functional MRI and diffusion tensor imaging (DTI) were used to assess the BGN activity and WM microstructural alterations. Results AR-PD patients showed significantly decreased 18F-DOPA uptake in caudate corpus compared to both IPD and controls, with a more symmetrical striatal dopaminergic denervation. Myocardial 18F-DOPA uptake in AR-PD was similar to controls, while it was significantly reduced in IPD. There was no significant difference in cortical 18F-FDG metabolism and functional activity of BGN between PD groups. The DTI data revealed more extensive WM microstructural damage in AR-PD compared to IPD. Conclusions AR-PD group showed additional significant decreased 18F-DOPA uptake in caudate corpus and more symmetrical striatal denervation. Additionally, relatively preserved myocardial innervation, cortical metabolic and WM microstructural changes suggest the possibility of “brain-first” type progression in AR-PD. Also, 18F-DOPA PET/CT may be a practical tool for evaluating dopaminergic innervation of striatum and heart together, but further evaluation is needed in this area.
dc.identifier.citationSoydaş Turan, B., Yalçın Çakmaklı, G., Lay Ergün, E., Daşgın H. ... Volkan Salancı, B. (2025). Multimodal imaging analysis of autosomal recessive Parkinson’s disease. Annals of Nuclear Medicine, 1-10. https://doi.org/10.1007/s12149-025-02053-4
dc.identifier.doi10.1007/s12149-025-02053-4
dc.identifier.eissn1864-6433
dc.identifier.endpage10
dc.identifier.issn0914-7187
dc.identifier.pmid40274726
dc.identifier.startpage1
dc.identifier.urihttps://dspace.mudanya.edu.tr/handle/20.500.14362/316
dc.identifier.wosqualityQ2
dc.institutionauthorDaşgın, Hacer
dc.language.isoen
dc.publisherSpringer
dc.relation.journalAnnals of Nuclear Medicine
dc.relation.publicationcategoryMakale- Uluslararası- Hakemli Dergi- Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.titleMultimodal imaging analysis of autosomal recessive Parkinson’s disease
dc.typeMakale
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Multimodal imaging analysis of autosomal recessive Parkinson’s disease.pdf
Size:
881.57 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.8 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
Tıbbi Görüntüleme Teknikleri Bölümü Koleksiyonu