Tıbbi Görüntüleme Teknikleri Bölümü Koleksiyonu

Permanent URI for this collection

https://dspace.mudanya.edu.tr/handle/20.500.14362/20

Browse

Browsing Tıbbi Görüntüleme Teknikleri Bölümü Koleksiyonu by Publisher "Springer"

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Interventional therapy of acute coronary syndromes in very old patient population and results of 2 years follow‑up
    (Springer, 2023) Boyraz, Bedrettin; Peker, Tezcan; Akgümüş, Alkame; Balun, Ahmet; 313898
    Background Research on cardiovascular treatment options and prognosis in very old age groups of patients is warranted. In our study, we evaluated and followed up on clinical conditions on admission and comorbidities of patients older than 80 years who were admitted to our hospital with acute myocardial infarction and shared our findings. Results A total of 144 patients were included in the study, with a mean age of 84.56 ± 5.01 years. No complications resulting in death or requiring surgery were observed in the patients. All-cause mortality was found to be related to heart failure, chronic pulmonary disease shock, and C-reactive protein levels. Cardiovascular mortality was correlated to heart failure, shock on admission, and C-reactive protein levels. No significant difference in mortality was observed between Non-ST elevated myocardial infarction and ST-elevation myocardial infarction. Conclusions Percutaneous coronary intervention is a safe treatment option with low complication and mortality rates in very old patients with acute coronary syndromes.
  • No Thumbnail Available
    Item
    Multimodal imaging analysis of autosomal recessive Parkinson’s disease
    (Springer, 2025-04) Soydaş Turan, Başak; Yalçın Çakmaklı, Gül; Lay Ergün, Eser; Daşgın, Hacer; Karlı Oğuz, Kader; Elibol, Bülent; Uğur, Ömer; Volkan Salancı, Bilge; 396621
    Objective Pathophysiological backgrounds of idiopathic Parkinson’s disease (IPD) and autosomal recessive monogenic Parkinson’s disease (AR-PD) have common features that can be assessed through multimodal imaging. In this study, the striatal and myocardial dopaminergic innervation, brain 18F-FDG metabolism, resting-state functional activity of basal ganglia network (BGN) and white-matter (WM) microstructure were evaluated in AR-PD with respect to IPD, to investigate whether AR-PD can be subtyped as “brain-first” parkinsonism according to recent etiopathogenetic classification effort. Methods Forty patients (17 with Parkin, 3 with DJ-1 mutations and 20 with IPD) were included. Striatal dopaminergic innervation was assessed semi-quantitatively by 18F-DOPA PET, and cardiac 18F-DOPA uptake was also evaluated. Brain 18F-FDG PET images were evaluated visually. Resting-state functional MRI and diffusion tensor imaging (DTI) were used to assess the BGN activity and WM microstructural alterations. Results AR-PD patients showed significantly decreased 18F-DOPA uptake in caudate corpus compared to both IPD and controls, with a more symmetrical striatal dopaminergic denervation. Myocardial 18F-DOPA uptake in AR-PD was similar to controls, while it was significantly reduced in IPD. There was no significant difference in cortical 18F-FDG metabolism and functional activity of BGN between PD groups. The DTI data revealed more extensive WM microstructural damage in AR-PD compared to IPD. Conclusions AR-PD group showed additional significant decreased 18F-DOPA uptake in caudate corpus and more symmetrical striatal denervation. Additionally, relatively preserved myocardial innervation, cortical metabolic and WM microstructural changes suggest the possibility of “brain-first” type progression in AR-PD. Also, 18F-DOPA PET/CT may be a practical tool for evaluating dopaminergic innervation of striatum and heart together, but further evaluation is needed in this area.