Tıbbi Görüntüleme Teknikleri Bölümü Koleksiyonu

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Browsing Tıbbi Görüntüleme Teknikleri Bölümü Koleksiyonu by All Authors "Elibol, Bülent"

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    Multimodal imaging analysis of autosomal recessive Parkinson’s disease
    (Springer, 2025-04) Soydaş Turan, Başak; Yalçın Çakmaklı, Gül; Lay Ergün, Eser; Daşgın, Hacer; Karlı Oğuz, Kader; Elibol, Bülent; Uğur, Ömer; Volkan Salancı, Bilge; 396621
    Objective Pathophysiological backgrounds of idiopathic Parkinson’s disease (IPD) and autosomal recessive monogenic Parkinson’s disease (AR-PD) have common features that can be assessed through multimodal imaging. In this study, the striatal and myocardial dopaminergic innervation, brain 18F-FDG metabolism, resting-state functional activity of basal ganglia network (BGN) and white-matter (WM) microstructure were evaluated in AR-PD with respect to IPD, to investigate whether AR-PD can be subtyped as “brain-first” parkinsonism according to recent etiopathogenetic classification effort. Methods Forty patients (17 with Parkin, 3 with DJ-1 mutations and 20 with IPD) were included. Striatal dopaminergic innervation was assessed semi-quantitatively by 18F-DOPA PET, and cardiac 18F-DOPA uptake was also evaluated. Brain 18F-FDG PET images were evaluated visually. Resting-state functional MRI and diffusion tensor imaging (DTI) were used to assess the BGN activity and WM microstructural alterations. Results AR-PD patients showed significantly decreased 18F-DOPA uptake in caudate corpus compared to both IPD and controls, with a more symmetrical striatal dopaminergic denervation. Myocardial 18F-DOPA uptake in AR-PD was similar to controls, while it was significantly reduced in IPD. There was no significant difference in cortical 18F-FDG metabolism and functional activity of BGN between PD groups. The DTI data revealed more extensive WM microstructural damage in AR-PD compared to IPD. Conclusions AR-PD group showed additional significant decreased 18F-DOPA uptake in caudate corpus and more symmetrical striatal denervation. Additionally, relatively preserved myocardial innervation, cortical metabolic and WM microstructural changes suggest the possibility of “brain-first” type progression in AR-PD. Also, 18F-DOPA PET/CT may be a practical tool for evaluating dopaminergic innervation of striatum and heart together, but further evaluation is needed in this area.