Sağlık Bilimleri Fakültesi
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Browsing Sağlık Bilimleri Fakültesi by Publisher "Springer"
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- ItemEffect of Limosilactobacillus reuteri DSM17938 to prevent antibiotic-associated diarrhea in children: prospective, multi-center, randomized, placebo-controlled clinical trial (PEARL Study)(Springer, 2025-06) Dinleyici, Ener Çağrı; Özen, Metehan; Güven, Şirin; Dalgıç, Nazan; Karbuz, Adem; Sütçü, Murat; Yazar, Ahmet Sami; 243394Antibiotic-associated diarrhea (AAD) is one of the side effects that occur during and after antibiotic use. Some probiotics have strain-specific beneficial effects on AAD development when used in combination with antibiotics. The aim of this study was to evaluate the effect of Limosilactobacillus reuteri DSM 17938 on the prevention of AAD in children. This is a prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial in T & uuml;rkiye between 2017-2019, among outpatient children with acute otitis media (AOM) or acute rhinosinusitis (ARS). Group 1 (n = 330) received amoxicillin-clavulanate and L. reuteri DSM 17938 (2 x 10(8) CFU) and Group 2 (n = 324) received amoxicillin-clavulanate and a placebo during the antibiotic treatment or continued for 21 days after antibiotic cessation. The primary end point of this study was the percentage of children with AAD in the first 14, 21, and 56 days of follow-up. Secondary endpoints are the percentage of children with AAD regarding the AOM vs ARS, amoxicillin-clavulanate dose, age groups, and the comparison between 14- and 21-days use of L. reuteri. The percentage of children with AAD was significantly lower in the L. reuteri group compared to the placebo group at 14 days (7.9% vs. 16.7%; RR: 0.47, 95%CI 0.30-0.7; p < 0.001); at 21 days (8.8% vs. 17.9%; RR: 0.49, 95%CI 0.32-0.74;p < 0.001); and at 56 days (9.1% vs. 19.6%; RR: 0.46, 95%CI 0.30-0.69;p < 0.001). The incidence of AAD was also significantly lower in the L. reuteri group at 14, 21 and 56 days among children aged between 6-24 months (p < 0.01, p < 0.01, p < 0.001) or children with AOM (p = 0.0001,p < 0.0001,p < 0.0001). When AAD was observed, the mean duration of diarrhea was longer in the placebo group(p < 0.05). Conclusions: This first study with L. reuteri DSM 17938 in a large pediatric outpatient setting showed significant reduction of AAD during the first 14 days of antibiotic use and the 8-week follow-up period. Trial Registration: NCT02765217 (First Submitted 02.05.2016) (https://clinicaltrials.gov/study/NCT02765217?term=NCT02765217&rank=1).
- ItemEnvironmental impact of athletes’ diets greenhouse gas emissions, water footprint, and sustainability awareness(Springer, 2026-01) Acar, Selva; Tuna, Tuğba; Ersoy, Nesli; 336342This cross-sectional study evaluated the environmental impact of athletes’ dietary patterns by estimating greenhouse gas emissions (GHGE) and water footprint (WF). It also assessed knowledge, attitudes, and behaviors related to sustainable nutrition using a structured questionnaire aligned with the FAO definition of sustainable diets. Conducted between January and August 2023 in Ankara, the study included 100 elite athletes (mean age: 21.0 ± 3.3 years; 65% female) from various sports disciplines. Dietary intake was assessed using a semi-quantitative food frequency questionnaire, and GHGE and WF values were calculated based on life cycle assessment data. The mean GHGE and WF values of athletes’ diets were 3017.1 ± 1877.4 g CO₂-eq/day and 5.4 ± 3.2 mL/g, respectively. Male athletes and strength/power athletes exhibited significantly higher dietary environmental impacts than female and team sports athletes (p < 0.001 and p < 0.05, respectively). Red meat and animal protein consumption were strongly associated with higher GHGE and WF values (p < 0.001). Despite the increasing importance of sustainability, more than 90% of participants lacked accurate knowledge of sustainable nutrition. Moreover, a discrepancy was observed between athletes’ stated willingness to support environmental values and their actual food choices, indicating an intention–behavior gap. This study contributes to the limited literature by quantifying the environmental impact of athletes’ diets while concurrently examining sustainability-related behavioral factors. The findings underscore the importance of integrating sustainability principles into sports nutrition planning and education to reduce environmental impacts while maintaining performance goals.
- ItemFuture Protein Sources in Sports Nutrition: Sustainable Solutions(Springer, 2026-02) Tuna, Tuğba; Ersoy, Nesli; 336342Purpose of ReviewThis review evaluates the potential of alternative protein sources, including plant-based proteins, insect proteins, mycoproteins, microalgae, and cultured meat, in meeting the increasing demand for sustainable and functional protein solutions in sports nutrition.Recent FindingsStudies indicate that alternative protein sources provide significant environmental benefits, such as reduced greenhouse gas emissions and lower water use, while delivering essential nutrients to support athletic performance and recovery. Advances in technology and production methods have further enhanced their feasibility as replacements for conventional animal-based proteins.SummaryIntegrating alternative protein sources into sports nutrition offers a dual benefit: meeting athletes' dietary requirements and supporting global sustainability goals. These protein sources pave the way for innovative, environmentally conscious dietary practices in sports nutrition, marking a pivotal shift toward a more sustainable future.
- ItemThe role of nutrition and nutritional supplements in the prevention and treatment of malnutrition in chronic obstructive pulmonary disease: current approaches in nutrition therapy(Springer, 2025-01) Tuna, Tuğba; Samur, Gülhan; 336342Purpose of Review Malnutrition is a significant comorbidity in Chronic Obstructive Pulmonary Disease (COPD), contributing to disease progression and reduced quality of life. This narrative review examines the role of nutritional therapy in the prevention and management of malnutrition in COPD, emphasizing evidence-based approaches and their clinical implications. Recent Findings COPD patients face increased metabolic demands, systemic inflammation, and reduced dietary intake, resulting in muscle wasting, sarcopenia, and cachexia. Recent evidence highlights the efficacy of targeted nutritional strategies, including essential amino acid supplementation, omega-3 fatty acids, vitamin D, and antioxidants, in improving respiratory function, muscle strength, and patient well-being. Comprehensive nutritional assessments and personalized interventions are increasingly recognized as critical components of COPD care. However, long-term efficacy data remain limited. Summary Nutritional therapy plays a pivotal role in managing malnutrition and improving clinical outcomes in COPD. This review synthesizes the latest evidence, identifies gaps in current research, and proposes strategies for integrating personalized nutrition into COPD care. Future studies are needed to establish the long-term benefits of these interventions and to develop tailored nutritional guidelines for COPD patients.
