The role of advanced glycation end-product levels measured by skin autofluorescence in the development of mitral annular calcification

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dc.authorid0000-0003-1831-182X
dc.authorscopusid57195950022
dc.authorwosidAAO-9394-2021
dc.contributor.authorBoyraz, Bedrettin
dc.contributor.authorPeker, Tezcan
dc.contributor.authorid313898
dc.date.accessioned2023-10-11T12:35:51Z
dc.date.available2023-10-11T12:35:51Z
dc.date.issued2023
dc.departmentFakülteler, Meslek Yüksekokulu, Tıbbi Görüntüleme Teknikleri Bölümü
dc.description.abstractAs a person ages, mitral annular calcification develops in the mitral annulus with increasing frequency. Lipid deposition, inflammation, and aging-related degeneration have been cited as potential causes of this pathophysiology, though there is currently no conclusive evidence to support this. AGEs accumulate in tissues due to the glycation of proteins and lipids, increasing the release of proinflammatory cytokines secondary to oxidative stress through the AGE receptor. The AGE levels increase in diabetic microvascular complications and degenerative aortic valve disease. Our study was planned prospectively as a case–control study involving 94 MAC-positive patients and 94 MAC-negative patients. The demographics, echocardiographic data and AGE levels of the patients were measured and recorded using the skin autofluorescence method. AGE levels were significantly higher in the MAC-positive patient group (3.2 vs. 2.7; p < 0.001). The AGE levels were observed as an independent predictor of MAC development in a regression analysis (OR: 8.05, 95% CI: 3.74–17.33, p < 0.001). In a ROC-curve analysis, the AUC was 0.79 (95% CI: 0.72–0.85). At a cut-off value of 2.7, 79.7% sensitivity and 69.1% specificity were observed. AGE levels can be used to cheaply, easily and non-invasively identify patients at risk of developing MAC.
dc.identifier.citationBoyraz, B., & Peker, T. (2023). The role of advanced glycation end-product levels measured by skin autofluorescence in the development of mitral annular calcification. Journal of cardiovascular development and disease, 10(9), 406. https://doi.org/10.3390/jcdd10090406
dc.identifier.doi10.3390/jcdd10090406
dc.identifier.endpage11
dc.identifier.issn2308-3425
dc.identifier.issue9
dc.identifier.pmid37754835
dc.identifier.startpage1
dc.identifier.urihttps://dspace.mudanya.edu.tr/handle/20.500.14362/169
dc.identifier.volume10
dc.identifier.wosqualityQ2
dc.institutionauthorBoyraz, Bedrettin
dc.language.isoen
dc.publisherMDPI
dc.relation.journalJournal of Cardiovascular Development and Disease
dc.relation.publicationcategoryMakale- Uluslararası- Hakemli Dergi- Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectAdvanced glycation end-products
dc.subjectMitral annular calcification
dc.subjectSkin autofluorescence
dc.titleThe role of advanced glycation end-product levels measured by skin autofluorescence in the development of mitral annular calcification
dc.typeMakale
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